Wenpeng Liu, Ph.D.

Primary Appointment:

Assistant Professor, Radiation Oncology Department, University of Virginia

Education and Training:

Vanderbilt University Postdoc 2017-2023 David Cortez Lab

Zhejiang University Ph.D. 2012-2017 Biochemistry and Molecular biology

California Institute of Technology Visiting scholar 2013-2015 Biochemistry

City of Hope. Radiation Oncology Department Training 2014-2015 Biochemistry

Zhejiang University B.S. 2008-2012 Biology

At Home

  1. Read books to kids
  2. Gardening work
  3. Woodworking
  4. Cooking
  5. Tiktoking
  6. Grants? Oh no…

Contact infomation

Email: Xbg5zt@virginia.edu

Phone: +1 434 924 2393

Publications:

  1. Liu, Wenpeng, Yuichiro Saito, Jessica Jackson, Rahul Bhowmick, Masato T. Kanemaki, Alessandro Vindigni, and David Cortez, RAD51 bypasses the CMG helicase to promote fork reversal. Science, 380,382-387(2023).DOI:10.1126/science.add7328 (2023)
  2. Liu, Wenpeng, Polaczek, P., Roubal, I., Meng, Y., Choe, W.-c., Caron, M.-C., Sedgeman, C.A., Xi, Y., Liu, C., Wu, Q., et al.. FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability. Nucleic Acids Research, gkad624, DOI:10.1093/nar/gkad624 (2023)
  3. Tamar Kavlashvili, Wenpeng Liu. Taha M Mohamed, David Cortez, and James M Dewar, Replication Fork Uncoupling Causes Nascent Strand Degradation and Fork Reversal. Nature Structural & Molecular Biology 30, 115–124. DOI:10.1038/s41594-022-00871-y (2023).
  4. Liu, Wenpeng. Single Molecular Resolution to Monitor DNA Replication Fork Dynamics upon Stress by DNA Fiber Assay. Bio-protocol 11, e4269. DOI:10.21769/BioProtoc.4269 (2021)
  5. Liu, Wenpeng, Krishnamoorthy, A., Zhao, R., and Cortez, D. Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors. Science Advances 6, 46, DOI: 10.1126/sciadv.abc3598. (2020)
  6. Meng, Y., Liu, C., Shen, L., Zhou, M., Liu, W., Kowolik, C., Campbell, J.L., Zheng, L., and Shen, B.. TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity. Nucleic Acids Research, 47, 7564-7579. DOI: 10.1093/nar/gkz537 (2019)
  7. Liu, Wenpeng, Zhou, M., Li, Z., Li, H., Polaczek, P., Dai, H., Wu, Q., Liu, C., Karanja, K.K., Popuri, V., et al.. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine 6, 73-86. DOI:10.1016/j.ebiom.2016.02.043 (2016)
  8. Liu, S., Lu, G., Ali, S., Liu, W., Zheng, L., Dai, H., Li, H., Xu, H., Hua, Y., Zhou, Y., et al.. Okazaki fragment maturation involves alpha-segment error editing by the mammalian FEN1/MutSalpha functional complex. EMBO J 34, 1829-1843. DOI: 10.15252/embj.201489865 (2015)
  9. Wang, J., Zhou, L., Li, Z., Zhang, T., Liu, W., Liu, Z., Yuan, Y.C., Su, F., Xu, L., Wang, Y., et al.. YY1 suppresses FEN1 over-expression and drug resistance in breast cancer. BMC Cancer 15, 50. DOI: 10.1186/s12885-015-1043-1 (2015)